5‑Hydroxytryptophan (5‑HTP) is derived from the Griffonia simplicifolia seed and is vital in the formation of serotonin and melatonin. While serotonin is usually created in the gut and central nervous system, it is not able to be absorbed by the blood-brain barrier, meaning it is unable to enter the CNS. Yet, 5‑HTP can cross the barrier where it is then used to generate serotonin - an important factor in esteem, sleep, feeling full, and sexual wellbeing.