Approximately 50% of the population contains genetic variations that limit the ability of methylenetetrahydrofolate reductase (MTHFR) enzymes to convert folic acid—the most typical form of folate found in dietary supplements and fortified foods—to L-methylfolate, the biologically active form of folate. Therefore, supplementing with L-methylfolate is often more effective for those with MTHFR gene variants.• Supports healthy mood, cardiovascular, and nerve function* 
• Important for normal production of serotonin, norepinephrine and dopamine*
• Essential for converting homocysteine to methionine*