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SAMe (S -Adenosylmethionine) 60 caps
SAMe (S -Adenosylmethionine) 60 caps
SAMe (S -Adenosylmethionine) 60 caps

SAMe (S -Adenosylmethionine) 60 caps


Pure Encapsulations





50 in stock.
Quantity must be 1 or more
Regular price $79.00

Enhanced stability SAMe to support methylation, positive mood, glutathione production and joint comfort*


SAMe (S-adenosylmethionine) can be found in every living cell and is a critical donor of methyl groups in more than 100 different biological processes. Methyl groups act as messengers to help control gene expression and cell function. This metabolite also serves as a precursor to glutathione and is involved in the fabrication of polyamines, crucial for optimal cell activities.


Clinical trials reveal that SAMe increases glutathione production in the liver and red blood cells. Over 40 studies show that SAMe also helps optimize cognitive function and positive mood. In a meta-analysis of 25 controlled trials that involved 791 people, remarkable support was found for improved mood, likely due to SAMe's action in promoting synthesis and activity of neurotransmitters such as dopamine and serotonin. 

It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity. Studies suggest it may enhance joint comfort and flexibility as well. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. It is believed to enhance joint comfort and function by supporting proteoglycan synthesis, as well as helping to stabilize and protect the proteoglycans.*

  • Supports cognitive and liver function*
  • Helps maintain joint comfort*
  • Made with hypoallergenic, vegan ingredients



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