Targets Nrf2 to support detoxification and antioxidant defenses*

Cruciferous veggies, such as broccoli, cauliflower, Brussels sprouts, and kale, are abundant in glucosinolates and thus support healthy cells and tissues. Ingesting and hydrolyzing these constituents converts them to isothiocyanates, of which sulforaphane is most powerful for activating phase II detoxification enzymes in the liver. Sulforaphane and resveratrol stimulate the Nrf2 transcription factor, boosting the expression of genes that promote protection against toxins and oxidative stress. 

Among these genes are glutathione peroxidase, superoxide dismutase and various phase II enzymes, such as glutathione sulfotransferases. Nrf2 also supports expression of glutathione glutamylcysteinyl ligase, which is responsible for a critical step in the biosynthesis of glutathione, a vital component of cellular antioxidant and detoxification systems. Found in virtually every cell of the body, glutathione plays essential roles in protein synthesis, synthesis and repair of DNA, enzyme function, transport, and cell maturation. Optimal levels of glutathione have been associated with physical and mental health.

The highest concentration of glutathione is found in the liver, where it offers antioxidant support, protects tissue and maintains detoxification. In a randomized clinical trial, supplementation with 250 and 1,000 mg of Setria® glutathione per day increased glutathione levels in the blood after one, three and six months. At six months, mean glutathione levels in the high-dose group increased 30-35% in erythrocytes, plasma and lymphocytes, and 260% in buccal cells (P<0.05). In the low-dose group, mean glutathione levels increased by 17% and 29% in blood and erythrocytes, respectively (P<0.05). Both glutathione dose groups showed support for antioxidant defenses, indicated by decreases in the oxidized-to-reduced-glutathione ratio in whole blood after six months.*

• Supports detoxification and antioxidant defenses on a cellular level*
• Helps maintain healthy cells and tissues*