Over a decade's worth of studies conducted across Europe and other regions have determined SAM-e (S-adenosyl-L-methionine, a necessary methylation and transulfuration cofactor) to be an effective aid in sustaining typical mood regulation, joint and liver health. SAM-e improves cell membrane fluidity, increases the number of neurotransmitter receptors, and encourages neurotransmitter receptor affinity. SAM-e promotes joint wellness by raising the count of articular chondrocytes and promoting the synthesis of sulfated proteoglycans..* 

SAM-e also protects synovial cells and helps block enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions.* SAM-e Plus tablets are enterically-coated, essential for preventing demethylation in the stomach.