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Pantethine is the stable, metabolically active form of pantothenic acid, or vitamin B5.* Pantethine is a vital component of coenzyme A, a cofactor for dozens of enzymatic reactions, including those involved with fat and carbohydrate metabolism.* Clinical trials suggest that, because its biochemical configuration is closer to coenzyme A than pantothenic acid, pantethine may have more benefit than pantothenic acid.* Pantethine appears to help metabolize fatty acids by activation of coenzyme A, promotion of carnitine transport of fatty acids into the mitochondria, and subsequent intra-mitochondrial oxidation of fatty acids.* All of these help improve energy production in every cell of the body.*
Consequently, pantethine supplementation has been found to support good cardiovascular health.* In addition, increases in beneficial HDL cholesterol and apolipoprotein A1 have been noted in association with pantethine supplementation.* Apolipoprotein A1 is the major protein component of HDL and promotes cholesterol removal from tissues to the liver for excretion.*
Pantethine is also considered the "anti-stress" vitamin because it supports healthy adrenal cortex function and hormone synthesis, particularly during times of stress.* Pantothenic acid deficiency can result in adrenal atrophy, which is characterized by increased fatigue, sleep disturbances, nausea, and abdominal discomfort.*
Take 1 capsule two to three times daily or as recommended by a health-care practitioner.